Issue 91, 2017
From the journal:

Chemical Communications

Taming photo-induced oxidation degradation of dihydropyridine drugs through cocrystallization†

Qihui Yu,ab   Zhicheng Yan,b   Junjie Bao,b   Jian-Rong Wang ORCID logo *b  and  Xuefeng Mei ORCID logo *b  

* Corresponding authors

a College of Pharmacy, Nanchang University, Nanchang 330006, China

b Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
E-mail: xuefengmei@simm.ac.cn, jrwang@simm.ac.cn
Fax: +86 2150807088
Tel: +86 2150800934

Abstract

Cocrystallization of nifedipine (NFD) and isonicotinamide (INA) resulted in two monotropic cocrystal polymorphs. The thermodynamically more stable polymorph presents superior photostability compared to the other. Cocrystallization can be an efficient approach to address the stability deficit of dihydropyridine drugs.

Graphical abstract: Taming photo-induced oxidation degradation of dihydropyridine drugs through cocrystallization

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C7CC06992H
Article type
Communication
Submitted
06 Sep 2017
Accepted
16 Oct 2017
First published
16 Oct 2017

Chem. Commun., 2017,53, 12266-12269

Permissions

Request permissions

Taming photo-induced oxidation degradation of dihydropyridine drugs through cocrystallization

Q. Yu, Z. Yan, J. Bao, J. Wang and X. Mei, Chem. Commun., 2017, 53, 12266 DOI: 10.1039/C7CC06992H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements