Issue 48, 2017
From the journal:

Chemical Communications

Two-photon imaging of formaldehyde in live cells and animals utilizing a lysosome-targetable and acidic pH-activatable fluorescent probe†

Xilei Xie,‡a   Fuyan Tang,‡a   Xiaoyan Shangguan,a   Shiyi Che,a   Jinye Niu,a   Yongsheng Xiao,a   Xu Wang*a  and  Bo Tang ORCID logo *a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China
E-mail: tangb@sdnu.edu.cn, wangxu@sdnu.edu.cn

Abstract

Lyso-TPFP presents lysosomal targetability and an acidic pH-activatable response toward formaldehyde. Thus, it exclusively visualizes lysosomal formaldehyde and is immune against it in neutral cytosol and other organelles. In addition, two-photon fluorescence imaging endows Lyso-TPFP with the capability of in situ tracking formaldehyde in live cells and animals.

Graphical abstract: Two-photon imaging of formaldehyde in live cells and animals utilizing a lysosome-targetable and acidic pH-activatable fluorescent probe

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Article information

DOI
https://doi.org/10.1039/C7CC03050A
Article type
Communication
Submitted
20 Apr 2017
Accepted
22 May 2017
First published
22 May 2017

Chem. Commun., 2017,53, 6520-6523

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Two-photon imaging of formaldehyde in live cells and animals utilizing a lysosome-targetable and acidic pH-activatable fluorescent probe

X. Xie, F. Tang, X. Shangguan, S. Che, J. Niu, Y. Xiao, X. Wang and B. Tang, Chem. Commun., 2017, 53, 6520 DOI: 10.1039/C7CC03050A

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