[11C]Cyanation of arylboronic acids in aqueous solutions

Abstract

A copper-mediated ¹¹C-cyanation method employing arylboronic acids and [¹¹C]HCN has been developed. This method was applied to the radiochemical synthesis of a wide range of aromatic ¹¹C-nitriles in aqueous solutions. The use of readily accessible arylboronic acids as precursors makes this method complementary to the well-established ¹¹C-cyanation methods that utilize aryl halide precursors.