Issue 52, 2016
From the journal:

Chemical Communications

Efficient access to alkynylated quinalizinones via the gold(i)-catalyzed aminoalkynylation of alkynes†

Popat S. Shinde,ab   Aslam C. Shaikhab  and  Nitin T. Patil*ab  

* Corresponding authors

a Division of Organic Chemistry, CSIR – National Chemical Laboratory, Dr. Homi Bhabha Road, Pune – 411 008, India
E-mail: n.patil@ncl.res.in

b Academy of Scientific and Innovative Research (AcSIR), New Delhi – 110 025, India

Abstract

The gold-catalyzed aminoalkynylation of alkynes for the synthesis of quinalizinones is reported. For instance, the reaction of pyridinoalkynes with 1-[(triisopropylsilyl)-ethynyl]-1,2-benziodoxol-3(1H)-one (TIPS-EBX) in the presence of a catalytic amount of AuCl at 50 °C afforded alkynylated quinalizinones in 57–87% yields.

Graphical abstract: Efficient access to alkynylated quinalizinones via the gold(i)-catalyzed aminoalkynylation of alkynes

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Article information

DOI
https://doi.org/10.1039/C6CC03414D
Article type
Communication
Submitted
23 Apr 2016
Accepted
23 May 2016
First published
23 May 2016

Chem. Commun., 2016,52, 8152-8155

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Efficient access to alkynylated quinalizinones via the gold(I)-catalyzed aminoalkynylation of alkynes

P. S. Shinde, A. C. Shaikh and N. T. Patil, Chem. Commun., 2016, 52, 8152 DOI: 10.1039/C6CC03414D

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