Issue 49, 2016, Issue in Progress
From the journal:

RSC Advances

Activity of N,N′-dialkyl-2-trifluoromethylthioimidazolium salts as phase-transfer catalyst for the alkylation of active methylene compounds†

Satoshi Mizuta,*a   Kanami Kitamura,a   Kodai Nishi,b   Ryo Hashimoto,c   Toshiya Usuic  and  Kenya Chibac  

* Corresponding authors

a Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki, Japan
E-mail: s-mizuta@nagasaki-u.ac.jp
Fax: +81 95 819 2864
Tel: +81 95 819 2863

b Department of Radioisotope Medicine, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Japan

c Nishiisahaya Hospital, 3015 Kaizu-machi, Isahaya, Nagasaki, Japan

Abstract

We herein report the synthesis of N,N′-dialkyl-2-trifluoromethylthioimidazolium salts from thioureas using nucleophilic trifluoromethylating reagents. The activity of imidazolium salts as phase-transfer catalysts under solid–liquid phase conditions was investigated for reactions such as the alkylation of active methylene compounds.

Graphical abstract: Activity of N,N′-dialkyl-2-trifluoromethylthioimidazolium salts as phase-transfer catalyst for the alkylation of active methylene compounds

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Article information

DOI
https://doi.org/10.1039/C6RA06870G
Article type
Communication
Submitted
15 Mar 2016
Accepted
21 Apr 2016
First published
03 May 2016

RSC Adv., 2016,6, 43159-43162

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Activity of N,N′-dialkyl-2-trifluoromethylthioimidazolium salts as phase-transfer catalyst for the alkylation of active methylene compounds

S. Mizuta, K. Kitamura, K. Nishi, R. Hashimoto, T. Usui and K. Chiba, RSC Adv., 2016, 6, 43159 DOI: 10.1039/C6RA06870G

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