Issue 8, 2016

Acid catalyzed synthesis of 2-(2-aminophenyl)quinazoline-4-amine and reaction with aromatic aldehydes

Abstract

The hydrochloride salt of 2-(2-aminophenyl)quinazoline-4-amine, prepared from a quinazolino[3,4-a]quinazoline, was reacted with aromatic aldehydes under conventional heating or microwave irradiation, leading to high yields of tetracyclic dihydroquinazolines.

Graphical abstract: Acid catalyzed synthesis of 2-(2-aminophenyl)quinazoline-4-amine and reaction with aromatic aldehydes

Supplementary files

Article information

Article type
Paper
Submitted
24 Sep 2015
Accepted
04 Jan 2016
First published
08 Jan 2016

RSC Adv., 2016,6, 6138-6143

Author version available

Acid catalyzed synthesis of 2-(2-aminophenyl)quinazoline-4-amine and reaction with aromatic aldehydes

E. Marinho and M. F. Proença, RSC Adv., 2016, 6, 6138 DOI: 10.1039/C5RA19785F

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