Pd-catalyzed aminocarbonylation of alkynes with amines using Co2(CO)8 as a carbonyl source

Abstract

A simple and mild protocol for the synthesis of 2-ynamides by palladium-catalyzed aminocarbonylation of alkynes was developed. The reaction proceeded at room temperature in air, utilizing Co₂(CO)₈ as a carbonyl source. This aminocarbonylation reaction features mild reaction conditions and good tolerance of substrates especially including aryl amines and primary amines.