Issue 10, 2016
From the journal:

Organic & Biomolecular Chemistry

Palladium-catalyzed direct arylation of indoles with arylsulfonyl hydrazides†

Congrong Liu,*a   Lianghui Ding,a   Guang Guo,a   Weiwei Liub  and  Fu-Lai Yangc  

* Corresponding authors

a School of Environment Engineering, Nanjing Institute of Technology, 1 Hongjingdadao, Nanjing, Jiangsu 211167, China
E-mail: congrong@njit.edu.cn
Fax: +86-025-86118974

b School of Communication Engineering, Nanjing Institute of Technology, 1 Hongjingdadao, Nanjing, Jiangsu 211167, China

c Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China

Abstract

A novel method to synthesise 2-arylindoles is demonstrated via direct arylation of indoles with arylsulfonyl hydrazides. Under the optimized reaction conditions, the reaction well tolerates a wide variety of functional groups to afford structurally diverse 2-arylindoles in good to excellent yields at 70 °C.

Graphical abstract: Palladium-catalyzed direct arylation of indoles with arylsulfonyl hydrazides

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Article information

DOI
https://doi.org/10.1039/C5OB02569A
Article type
Communication
Submitted
15 Dec 2015
Accepted
04 Feb 2016
First published
05 Feb 2016

Org. Biomol. Chem., 2016,14, 2824-2827

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Palladium-catalyzed direct arylation of indoles with arylsulfonyl hydrazides

C. Liu, L. Ding, G. Guo, W. Liu and F. Yang, Org. Biomol. Chem., 2016, 14, 2824 DOI: 10.1039/C5OB02569A

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