Issue 2, 2016
From the journal:

Organic & Biomolecular Chemistry

A versatile approach to flavones via a one-pot Pd(ii)-catalyzed dehydrogenation/oxidative boron-Heck coupling sequence of chromanones†

Jun Lee,‡a   Jihyun Yu,‡a   Seung Hwan Son,a   Jinyuk Heo,a   Taelim Kim,b   Ji-Young An,a   Kyung-Soo Inna  and  Nam-Jung Kim*a  

* Corresponding authors

a College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, Republic of Korea
E-mail: kimnj@khu.ac.kr
Fax: (+82) 2-966-3885
Tel: (+82) 2-961-0580

b Department of Life and Nanopharmaceutical Science, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, Republic of Korea

Abstract

A variety of flavones were expediently synthesized from readily accessible chromanones via a one-pot sequence involving Pd(II)-catalyzed dehydrogenation and oxidative boron-Heck coupling with arylboronic acid pinacol esters. In particular, the use of arylboronic acid pinacol esters was found to significantly improve the yield of the reaction.

Graphical abstract: A versatile approach to flavones via a one-pot Pd(ii)-catalyzed dehydrogenation/oxidative boron-Heck coupling sequence of chromanones

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Article information

DOI
https://doi.org/10.1039/C5OB01911G
Article type
Paper
Submitted
15 Sep 2015
Accepted
13 Nov 2015
First published
13 Nov 2015

Org. Biomol. Chem., 2016,14, 777-784

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A versatile approach to flavones via a one-pot Pd(II)-catalyzed dehydrogenation/oxidative boron-Heck coupling sequence of chromanones

J. Lee, J. Yu, S. H. Son, J. Heo, T. Kim, J. An, K. Inn and N. Kim, Org. Biomol. Chem., 2016, 14, 777 DOI: 10.1039/C5OB01911G

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