Liposome antibody–ionophore conjugate antiproliferative activity increases by cellular metallostasis alteration

Antonella Accardo; Luisa Del Zoppo; Giancarlo Morelli; Daniele F. Condorelli; Vincenza Barresi; Nicolò Musso; Giorgia Spampinato; Francesco Bellia; Giovanni Tabbì; Enrico Rizzarelli

doi:10.1039/C6MD00461J

Liposome antibody–ionophore conjugate antiproliferative activity increases by cellular metallostasis alteration†‡

Antonella Accardo,^a Luisa Del Zoppo,^a Giancarlo Morelli,*^a Daniele F. Condorelli,^b Vincenza Barresi,*^b Nicolò Musso,^b Giorgia Spampinato,^b Francesco Bellia,^c Giovanni Tabbì^c and Enrico Rizzarelli*^cd

Author affiliations

* Corresponding authors

^a Department of Pharmacy, CIRPeB, University of Naples “Federico II,” and IBB-CNR, Via Mezzocannone 16, 80134 Naples, Italy
E-mail: gmorelli@unina.it

^b Section of Medical Biochemistry, Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia 97, 95125 Catania, Italy
E-mail: barregi@unict.it

^c Institute of Biostructures and Bioimaging, National Research Council (CNR), via P. Gaifami 18, 95126 Catania, Italy
E-mail: erizzarelli@unict.it

^d Department of Chemical Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy

Abstract

Carnosine derivative containing liposomes functionalized with the Fab' fragment of Trastuzumab were synthesized. They represent a new class of antibody–drug conjugates because carnosine acts as an ionophore for Cu²⁺ or Zn²⁺, altering the metallostasis of cancer cells, leading to their death.

MedChemComm

Liposome antibody–ionophore conjugate antiproliferative activity increases by cellular metallostasis alteration†‡

Abstract

Supplementary files

Article information

Download Citation

Permissions

Liposome antibody–ionophore conjugate antiproliferative activity increases by cellular metallostasis alteration

Search articles by author

Spotlight

Advertisements