Issue 7, 2016
From the journal:

Green Chemistry

Cyclopropanes in water: a diastereoselective synthesis of substituted 2H-chromen-2-one and quinolin-2(1H)-one linked cyclopropanes†

Ashish Anand,a   Jayashree Yenagi,b   J. Tonannavarb  and  Manohar V. Kulkarni*a  

* Corresponding authors

a Department of Studies in Chemistry, Karnatak University, Pavate Nagar, Dharwad 580003, Karnataka, India
E-mail: manohar274@gmail.com

b Department of Studies in Physics, Karnatak University, Pavate Nagar, Dharwad 580003, Karnataka, India

Abstract

A one-pot three component reaction has been developed for the synthesis of substituted cyclopropanes employing 4-bromomethyl-2H-chromen-2-one/quinolin-2(1H)-ones, aromatic aldehydes and activated nitriles. The room temperature reaction in aqueous medium has been found to be diastereoselective and high yielding.

Graphical abstract: Cyclopropanes in water: a diastereoselective synthesis of substituted 2H-chromen-2-one and quinolin-2(1H)-one linked cyclopropanes

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Article information

DOI
https://doi.org/10.1039/C5GC02443A
Article type
Paper
Submitted
10 Oct 2015
Accepted
26 Nov 2015
First published
27 Nov 2015

Green Chem., 2016,18, 2201-2205

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Cyclopropanes in water: a diastereoselective synthesis of substituted 2H-chromen-2-one and quinolin-2(1H)-one linked cyclopropanes

A. Anand, J. Yenagi, J. Tonannavar and M. V. Kulkarni, Green Chem., 2016, 18, 2201 DOI: 10.1039/C5GC02443A

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