Issue 27, 2016
From the journal:

Dalton Transactions

Novel class of Bi(iii) hydroxamato complexes: synthesis, urease inhibitory activity and activity against H. pylori†

D. M. Keogan,a   B. Twamley,b   D. Fitzgerald-Hughesc  and  D. M. Griffith*a  

* Corresponding authors

a Centre for Synthesis & Chemical Biology, Department of Pharmaceutical & Medicinal Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 2, Ireland
E-mail: dgriffith@rcsi.ie

b School of Chemistry, Chemistry Building, Trinity College Dublin, Dublin 2, Ireland

c RCSI Microbiology, Royal College of Surgeons in Ireland, RCSI Education & Research Centre, Beaumont Hospital, Beaumont, Dublin 9, Ireland

Abstract

Reaction of Bi(NO3)3 with benzohydroxamic acid (Bha) and salicylhydroxamic acid (Sha) gives the novel Bi(III) complexes [Bi2(Bha-1H)2(μ-Bha-1H)2(η2-NO3)2] (1) and [Bi6(CH3OH)2(η1-NO3)2(η2-NO3)(OH2)2(Sha-1H)12](NO3)2 (2). X-ray crystal structure of 1 reveals two hydroxamato coordination modes; bidentate bridging (O, O′) and bidentate non-bridging (O, O′) and of 2 reveals one coordination mode; bidentate bridging (O, O′). 1, specifically designed to and demonstrated to inhibit the activity of urease, exhibits excellent antibacterial activity against three strains of Helicobacter pylori with MIC ≥ 16 μg mL−1.

Graphical abstract: Novel class of Bi(iii) hydroxamato complexes: synthesis, urease inhibitory activity and activity against H. pylori

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Article information

DOI
https://doi.org/10.1039/C5DT05061H
Article type
Paper
Submitted
30 Dec 2015
Accepted
06 Jun 2016
First published
10 Jun 2016

Dalton Trans., 2016,45, 11008-11014

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Novel class of Bi(III) hydroxamato complexes: synthesis, urease inhibitory activity and activity against H. pylori

D. M. Keogan, B. Twamley, D. Fitzgerald-Hughes and D. M. Griffith, Dalton Trans., 2016, 45, 11008 DOI: 10.1039/C5DT05061H

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