Issue 86, 2016
From the journal:

Chemical Communications

A ligation-based loop-mediated isothermal amplification (ligation-LAMP) strategy for highly selective microRNA detection†

Wenfang Du,a   Mengmei Lv,a   Junjie Li,a   Ruqin Yu*a  and  Jianhui Jiang*a  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China
E-mail: jianhuijiang@hnu.edu.cn, rqyu@hnu.edu.cn
Fax: 86-731-88822872
Tel: 86-731-88822577

Abstract

A novel ligation-based loop-mediated isothermal amplification (ligation-LAMP) method has been developed for miRNA detection, which enables highly selective and sensitive quantitative detection of miR-21 in a dynamic range from 1 fM to 1 nM with the ability to discriminate single-base mismatches.

Graphical abstract: A ligation-based loop-mediated isothermal amplification (ligation-LAMP) strategy for highly selective microRNA detection

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Article information

DOI
https://doi.org/10.1039/C6CC06160E
Article type
Communication
Submitted
26 Jul 2016
Accepted
27 Sep 2016
First published
30 Sep 2016

Chem. Commun., 2016,52, 12721-12724

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A ligation-based loop-mediated isothermal amplification (ligation-LAMP) strategy for highly selective microRNA detection

W. Du, M. Lv, J. Li, R. Yu and J. Jiang, Chem. Commun., 2016, 52, 12721 DOI: 10.1039/C6CC06160E

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