Issue 73, 2016
From the journal:

Chemical Communications

Membrane-disrupting iridium(iii) oligocationic organometallopeptides†

Iria Salvadó,a   Ilaria Gamba,a   Javier Montenegro, ORCID logo b   José Martínez-Costas,c   Jose Manuel Brea,d   María Isabel Loza,d   Miguel Vázquez López*a  and  M. Eugenio Vázquez ORCID logo *b  

* Corresponding authors

a Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Inorgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
E-mail: miguel.vazquez.lopez@usc.es

b Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
E-mail: eugenio.vazquez@usc.es

c Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Bioquímica y Biología Molecular, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain

d Grupo de Investigación BioFarma/Plataforma de Screening USEF, Centro de Investigación CIMUS, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain

Abstract

A series of oligoarginine peptide derivatives containing cyclometallated iridium(III) units display remarkable cytotoxicity, comparable to that of cisplatin. In vitro studies with unilamellar vesicles support a membrane-disrupting mechanism of action.

Graphical abstract: Membrane-disrupting iridium(iii) oligocationic organometallopeptides

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Article information

DOI
https://doi.org/10.1039/C6CC05537K
Article type
Communication
Submitted
04 Jul 2016
Accepted
12 Aug 2016
First published
19 Aug 2016

Chem. Commun., 2016,52, 11008-11011

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Membrane-disrupting iridium(III) oligocationic organometallopeptides

I. Salvadó, I. Gamba, J. Montenegro, J. Martínez-Costas, J. M. Brea, M. I. Loza, M. Vázquez López and M. E. Vázquez, Chem. Commun., 2016, 52, 11008 DOI: 10.1039/C6CC05537K

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