Issue 65, 2016
From the journal:

Chemical Communications

An AIE-active fluorescence turn-on bioprobe mediated by hydrogen-bonding interaction for highly sensitive detection of hydrogen peroxide and glucose†

Zhegang Song,‡a   Ryan T. K. Kwok,‡a   Dan Ding,b   Han Nie,a   Jacky W. Y. Lam,a   Bin Liuc  and  Ben Zhong Tang*a  

* Corresponding authors

a Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study, Division of Biomedical Engineering, Division of Life Science, State Key Laboratory of Molecular Neuroscience and Institute of Molecular Functional Materials, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
E-mail: tangbenz@ust.hk

b State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education and College of Life Sciences, Nankai University, Tianjin 300071, China

c Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585

Abstract

An AIE-active “turn-on” bioprobe is designed for hydrogen peroxide detection based on an imine-functionalized tetraphenylethene derivative. The linear fluorescence response enables quantification of hydrogen peroxide with superior sensitivity and selectivity. Meanwhile, glucose assay is also realized by taking advantage of GOx/glucose enzymatic reaction.

Graphical abstract: An AIE-active fluorescence turn-on bioprobe mediated by hydrogen-bonding interaction for highly sensitive detection of hydrogen peroxide and glucose

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Article information

DOI
https://doi.org/10.1039/C6CC05049B
Article type
Communication
Submitted
16 Jun 2016
Accepted
19 Jul 2016
First published
19 Jul 2016

Chem. Commun., 2016,52, 10076-10079

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An AIE-active fluorescence turn-on bioprobe mediated by hydrogen-bonding interaction for highly sensitive detection of hydrogen peroxide and glucose

Z. Song, R. T. K. Kwok, D. Ding, H. Nie, J. W. Y. Lam, B. Liu and B. Z. Tang, Chem. Commun., 2016, 52, 10076 DOI: 10.1039/C6CC05049B

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