A novel anticancer theranostic pro-prodrug based on hypoxia and photo sequential control

Weipei Feng; Chunyue Gao; Wei Liu; Huihui Ren; Chao Wang; Kun Ge; Shenghui Li; Guoqiang Zhou; Hongyan Li; Shuxiang Wang; Guang Jia; Zhenhua Li; Jinchao Zhang

doi:10.1039/C6CC02932A

A novel anticancer theranostic pro-prodrug based on hypoxia and photo sequential control†

Weipei Feng,^a Chunyue Gao,^a Wei Liu,^a Huihui Ren,^a Chao Wang,^a Kun Ge,^a Shenghui Li,^ab Guoqiang Zhou,^ab Hongyan Li,^a Shuxiang Wang,*^ab Guang Jia,^ab Zhenhua Li^ab and Jinchao Zhang*^ab

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* Corresponding authors

^a Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China

^b Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Baoding 071002, China
E-mail: wsx@hbu.edu.cn, jczhang6970@163.com

Abstract

A novel anticancer pro-prodrug (GMC-CA_E-NO₂) with diagnosis and therapy functions based on hypoxia and photo sequential control was designed. It provides a platform for constructing theranostic pro-prodrugs to release active drugs controlled by hypoxic status and UV illumination.

Chemical Communications

A novel anticancer theranostic pro-prodrug based on hypoxia and photo sequential control†

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A novel anticancer theranostic pro-prodrug based on hypoxia and photo sequential control

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