Issue 37, 2016
From the journal:

Chemical Communications

A charge-adaptive nanosystem for prolonged and enhanced in vivo antibiotic delivery†

Liping Chu,‡a   Honglin Gao,‡a   Tangjian Cheng,b   Yumin Zhang,a   Jinjian Liu,a   Fan Huang,a   Cuihong Yang,*a   Linqi Shi*b  and  Jianfeng Liu*a  

* Corresponding authors

a Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, P. R. China
E-mail: yangcuihong1983@163.com, lewis78@163.com

b State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, P. R. China
E-mail: shilinqi@nankai.edu.cn

Abstract

Herein we report on a charge-adaptive nanosystem for prolonged and enhanced in vivo antibiotic delivery. The nanocarrier achieves acid-dependent charge conversion, thus prolonging the circulation time and enhancing antibiotic accumulation in subcutaneous inflammation models.

Graphical abstract: A charge-adaptive nanosystem for prolonged and enhanced in vivo antibiotic delivery

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Article information

DOI
https://doi.org/10.1039/C6CC01269H
Article type
Communication
Submitted
10 Feb 2016
Accepted
04 Apr 2016
First published
04 Apr 2016

Chem. Commun., 2016,52, 6265-6268

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A charge-adaptive nanosystem for prolonged and enhanced in vivo antibiotic delivery

L. Chu, H. Gao, T. Cheng, Y. Zhang, J. Liu, F. Huang, C. Yang, L. Shi and J. Liu, Chem. Commun., 2016, 52, 6265 DOI: 10.1039/C6CC01269H

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