Issue 20, 2016
From the journal:

Chemical Communications

Dual pH-responsive 5-aminolevulinic acid pseudopolyrotaxane prodrug micelles for enhanced photodynamic therapy†

Hongxin Tong,a   Yin Wang,a   Huan Li,a   Qiao Jin*a  and  Jian Ji*a  

* Corresponding authors

a MOE Key Laboratory of Macromolecular Synthesis, Functionalization, Department of Polymer Science, Engineering, Zhejiang University, Hangzhou 310027, China
E-mail: jinqiao@zju.edu.cn, jijian@zju.edu.cn
Fax: +86-571-87953729
Tel: +86-571-87953729

Abstract

Novel 5-aminolevulinic acid (ALA) pseudopolyrotaxane prodrug micelles with dual pH-responsive properties were prepared by the host–guest interaction of α-cyclodextrin (α-CD) and poly(ethylene glycol) (PEG). The micelles exhibited pH dependent cellular uptake and pH-sensitive ALA release, enabling enhanced photodynamic therapy.

Graphical abstract: Dual pH-responsive 5-aminolevulinic acid pseudopolyrotaxane prodrug micelles for enhanced photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/C6CC00450D
Article type
Communication
Submitted
17 Jan 2016
Accepted
08 Feb 2016
First published
08 Feb 2016

Chem. Commun., 2016,52, 3966-3969

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Dual pH-responsive 5-aminolevulinic acid pseudopolyrotaxane prodrug micelles for enhanced photodynamic therapy

H. Tong, Y. Wang, H. Li, Q. Jin and J. Ji, Chem. Commun., 2016, 52, 3966 DOI: 10.1039/C6CC00450D

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