Issue 13, 2016
From the journal:

Chemical Communications

Iron-catalysed sequential reaction towards α-aminonitriles from secondary amines, primary alcohols and trimethylsilyl cyanide†

Hang Shen,a   Liangzhen Hu,a   Qing Liu,a   Muhammad Ijaz Hussain,a   Jing Pan,a   Mingming Huanga  and  Yan Xiong*ab  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030, China
E-mail: xiong@cqu.edu.cn

b State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China

Abstract

We have developed a one-pot iron-catalysed sequential reaction of secondary amines with primary alcohols, trimethylsilyl cyanide and TBHP under mild reaction conditions to give the corresponding α-aminonitriles.

Graphical abstract: Iron-catalysed sequential reaction towards α-aminonitriles from secondary amines, primary alcohols and trimethylsilyl cyanide

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Article information

DOI
https://doi.org/10.1039/C5CC10346K
Article type
Communication
Submitted
17 Dec 2015
Accepted
04 Jan 2016
First published
04 Jan 2016

Chem. Commun., 2016,52, 2776-2779

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Iron-catalysed sequential reaction towards α-aminonitriles from secondary amines, primary alcohols and trimethylsilyl cyanide

H. Shen, L. Hu, Q. Liu, M. I. Hussain, J. Pan, M. Huang and Y. Xiong, Chem. Commun., 2016, 52, 2776 DOI: 10.1039/C5CC10346K

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