Issue 17, 2016
From the journal:

Chemical Communications

Drug–drug co-crystallization presents a new opportunity for the development of stable vitamins†

Jian-Rong Wang,a   Qihui Yu,a   Wenjuan Daia  and  Xuefeng Mei*a  

* Corresponding authors

a Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
E-mail: xuefengmei@simm.ac.cn

Abstract

Drug–drug co-crystallization could realize combination drugs at a molecular level. Two polymorphic co-crystals between VD2 and VD3 were successfully designed and synthesized. These enantiotropic polymorphs exhibit significantly different physicochemical stabilities.

Graphical abstract: Drug–drug co-crystallization presents a new opportunity for the development of stable vitamins

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Article information

DOI
https://doi.org/10.1039/C5CC10297A
Article type
Communication
Submitted
16 Dec 2015
Accepted
27 Jan 2016
First published
27 Jan 2016

Chem. Commun., 2016,52, 3572-3575

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Drug–drug co-crystallization presents a new opportunity for the development of stable vitamins

J. Wang, Q. Yu, W. Dai and X. Mei, Chem. Commun., 2016, 52, 3572 DOI: 10.1039/C5CC10297A

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