Issue 13, 2016
From the journal:

Chemical Communications

A new class of Ru(ii) polyazine agents with potential for photodynamic therapy†

Roberto Padilla,a   José A. Rodriguez-Corrales,a   Lauren E. Donohoe,a   Brenda S. J. Winkel*b  and  Karen J. Brewer‡a  

* Corresponding authors

a Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0212, USA

b Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0406, USA
E-mail: winkel@vt.edu

Abstract

Appending anthracene units to [(bpy)2Ru(dpp)]2+ results in Ru(II) agents that exhibit dynamic photoreactivity towards DNA and protein. [(Anthbpy)(bpy)Ru(dpp)]2+ and [(Anthbpy)2Ru(dpp)]2+ are the first metal–organic Ru(II) agent with dpp ligands shown to photomodify DNA in the presence or absence of oxygen, while also binding protein in an oxygen-dependent manner.

Graphical abstract: A new class of Ru(ii) polyazine agents with potential for photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/C5CC08682E
Article type
Communication
Submitted
19 Oct 2015
Accepted
31 Dec 2015
First published
04 Jan 2016

Chem. Commun., 2016,52, 2705-2708

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A new class of Ru(II) polyazine agents with potential for photodynamic therapy

R. Padilla, J. A. Rodriguez-Corrales, L. E. Donohoe, B. S. J. Winkel and K. J. Brewer, Chem. Commun., 2016, 52, 2705 DOI: 10.1039/C5CC08682E

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