Issue 4, 2015
From the journal:

Green Chemistry

One-pot highly diastereoselective annulation to N-unprotected tetrasubstituted 2-pyrrolines†

Sara Meninno,a   Amedeo Capobianco,a   Andrea Pelusoa  and  Alessandra Lattanzi*a  

* Corresponding authors

a Dipartimento di Chimica e Biologia, Università di Salerno, Via Giovanni Paolo II, Fisciano, Italy
E-mail: lattanzi@unisa.it
Fax: +39-089-969603

Abstract

A one-pot DABCO-catalysed Michael addition of glycine imine-derived esters to trans-2-aroyl-3-arylacrylonitriles followed by a deprotection/cyclization/tautomerization sequence afforded tetrasubstituted N-unprotected trans-2-pyrrolines in up to 96% yield.

Graphical abstract: One-pot highly diastereoselective annulation to N-unprotected tetrasubstituted 2-pyrrolines

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Article information

DOI
https://doi.org/10.1039/C4GC02191F
Article type
Communication
Submitted
10 Nov 2014
Accepted
05 Jan 2015
First published
06 Jan 2015

Green Chem., 2015,17, 2137-2140

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One-pot highly diastereoselective annulation to N-unprotected tetrasubstituted 2-pyrrolines

S. Meninno, A. Capobianco, A. Peluso and A. Lattanzi, Green Chem., 2015, 17, 2137 DOI: 10.1039/C4GC02191F

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