Issue 24, 2015

Metallacrowns as products of the aqueous medium self-assembly of histidinehydroxamic acid-containing polypeptides

Abstract

Self-assembly is a widely studied, spontaneous, and reversible phenomenon leading to the formation of the ordered structures by non-covalent specific interactions among starting molecules. In this work, a new template for the self-assembly of polypeptides based on peptides containing the C-terminal histidinehydroxamic acid moiety and Cu2+ ions is characterized. Two peptide (tripeptide and pentadecapeptide) hydroxamic acid systems were synthesized and their interactions with Cu2+ ions were investigated, revealing a high stability of the supramolecular assemblies formed. The supramolecular metallacrown-based L4Cu5 complexes exist at physiological pH in the presence of Cu2+ ions as is evidenced from the spectroscopic methods, ESI mass spectrometry, and physicochemical techniques.

Graphical abstract: Metallacrowns as products of the aqueous medium self-assembly of histidinehydroxamic acid-containing polypeptides

Supplementary files

Article information

Article type
Paper
Submitted
02 Apr 2015
Accepted
07 May 2015
First published
08 May 2015

Dalton Trans., 2015,44, 11172-11181

Author version available

Metallacrowns as products of the aqueous medium self-assembly of histidinehydroxamic acid-containing polypeptides

M. Cal, A. Kotynia, Ł. Jaremko, M. Jaremko, M. Lisowski, M. Cebo, J. Brasuń and P. Stefanowicz, Dalton Trans., 2015, 44, 11172 DOI: 10.1039/C5DT01267H

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