A membrane permeable fluorescent Ca2+ probe based on bis-BODIPY with branched PEG

Wenfeng Duan; Huimin Wei; Tengbo Cui; Baoxiang Gao

doi:10.1039/C4TB01457J

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A membrane permeable fluorescent Ca²⁺ probe based on bis-BODIPY with branched PEG†

Wenfeng Duan,‡^a Huimin Wei,‡^a Tengbo Cui^a and Baoxiang Gao*^ab

Author affiliations

* Corresponding authors

^a Key Laboratory of Analytical Science and Technology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding, China

^b Key Laboratory of Medicinal Chemistry and Molecular Diagnosis(Hebei University), Ministry of Education, Baoding, China
E-mail: bxgao@hbu.edu.cn
Fax: +86 3125077374

Abstract

A new class of Ca²⁺ probes is developed based on PEG–BODIPY–BAPTA conjugates. These newly formed probes with BAPTA acid exhibit high sensitivity and selectivity for Ca²⁺ over other metal ions, can pass through the cell membranes of living cells without special procedures, and can monitor changes in the intracellular Ca²⁺ signal.

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Article information

DOI: https://doi.org/10.1039/C4TB01457J
Article type: Paper
Submitted: 02 Sep 2014
Accepted: 25 Nov 2014
First published: 27 Nov 2014

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J. Mater. Chem. B, 2015,3, 894-898

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A membrane permeable fluorescent Ca²⁺ probe based on bis-BODIPY with branched PEG

W. Duan, H. Wei, T. Cui and B. Gao, J. Mater. Chem. B, 2015, 3, 894 DOI: 10.1039/C4TB01457J

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Journal of Materials Chemistry B