Issue 99, 2015
From the journal:

RSC Advances

Porous PLGA microparticles to encapsulate doxorubicin and polyethylenimine/miR-34a for inhibiting the proliferation and migration of lung cancer†

Chenhui Wang,‡a   Di Wu,‡a   Jiebing Yang,a   Haobo Han,a   Zhen Xing,a   Yan Zhang,a   Yan Yang*a  and  Quanshun Li*a  

* Corresponding authors

a Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China
E-mail: quanshun@jlu.edu.cn, yyan@jlu.edu.cn
Fax: +86-431-85155200
Tel: +86-431-85155216

Abstract

Porous PLGA microparticles were successfully prepared for achieving the co-delivery of doxorubicin and PEI25K/miR-34a, using ammonium bicarbonate as a porogen. The synergistic effect between these two components ensured the efficient anti-proliferative and anti-migration effects of porous PLGA microparticles on tumor cells.

Graphical abstract: Porous PLGA microparticles to encapsulate doxorubicin and polyethylenimine/miR-34a for inhibiting the proliferation and migration of lung cancer

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Article information

DOI
https://doi.org/10.1039/C5RA15516A
Article type
Communication
Submitted
04 Aug 2015
Accepted
21 Sep 2015
First published
21 Sep 2015

RSC Adv., 2015,5, 81445-81448

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Porous PLGA microparticles to encapsulate doxorubicin and polyethylenimine/miR-34a for inhibiting the proliferation and migration of lung cancer

C. Wang, D. Wu, J. Yang, H. Han, Z. Xing, Y. Zhang, Y. Yang and Q. Li, RSC Adv., 2015, 5, 81445 DOI: 10.1039/C5RA15516A

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