SNAr reaction in aqueous medium in the presence of mixed organic and inorganic bases

Nilesh B. Shelke; Ramrao Ghorpade; Ajay Pratap; Vijay Tak; B. N. Acharya

doi:10.1039/C5RA03510D

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S_NAr reaction in aqueous medium in the presence of mixed organic and inorganic bases†

Nilesh B. Shelke,^a Ramrao Ghorpade,^a Ajay Pratap,^a Vijay Tak^b and B. N. Acharya*^a

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* Corresponding authors

^a Process Technology Development Division, Defence R & D Establishment, Jhansi Road, Gwalior-474002, MP, India
E-mail: bnacharya@drde.drdo.in, bnacharya@yahoo.com

^b Vertox Laboratory, Defence R & D Establishment, Jhansi Road, Gwalior-474002, MP, India

Abstract

N-Arylation of amines with fluorobenzonitriles in aqueous medium is described. A mixture of N,N-diisopropylethyl amine and Na₂CO₃ (1 : 1) is found to achieve maximum conversion by refluxing for 3 hours in water. The product can be easily isolated by solvent extraction.

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Article information

DOI: https://doi.org/10.1039/C5RA03510D
Article type: Communication
Submitted: 26 Feb 2015
Accepted: 25 Mar 2015
First published: 26 Mar 2015

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RSC Adv., 2015,5, 31226-31230

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S_NAr reaction in aqueous medium in the presence of mixed organic and inorganic bases

N. B. Shelke, R. Ghorpade, A. Pratap, V. Tak and B. N. Acharya, RSC Adv., 2015, 5, 31226 DOI: 10.1039/C5RA03510D

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