The domino reaction of 5-alkoxy- or 5-aminoisoxazoles, under metal relay catalysis, with symmetric 1,3-diketones gives 4-acylpyrrole-2-carboxylic acid derivatives in high yield. Esters and amides of acylacetic acids react regioselectively, giving derivatives of pyrrole-2,4-dicarboxylic acid as the main products.
E. E. Galenko, A. V. Galenko, A. F. Khlebnikov and M. S. Novikov, RSC Adv., 2015, 5, 18172 DOI: 10.1039/C5RA01889G
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