Issue 27, 2015

Molecular insight and resolution for tumors harboring the H-ras(G12V) mutation

Abstract

A study about the physiological regulators of oncogenic growth has recently been published in the literature. When the H-ras gene mutates, the mutant H-ras(G12V) protein causes uncontrolled cell growth. We tried to observe whether there is any difference between the wild type and mutant H-ras protein in terms of the molecular character and structural variation in silico. Our hypothesis is that the H-ras(G12V) protein, accompanied by an altered structure, might be responsible for excess signal transduction and even tumor formation. In this study, we wanted to find a potent compound that could bind to the H-ras(G12V) protein and interfere with the phosphorylation of the substrate protein. By using homology modeling, structure-based docking, candidate screening, and molecular dynamics (MD) simulations, we demonstrated that the structural and molecular character of the H-ras and H-ras(G12V) proteins were different. Abrine could bind to H-ras(G12V) and might interfere with the phosphorylation process. These results provided novel insight for the management of tumors or cancers, which harbor the H-ras(G12V) mutation.

Graphical abstract: Molecular insight and resolution for tumors harboring the H-ras(G12V) mutation

Article information

Article type
Paper
Submitted
28 Dec 2014
Accepted
05 Feb 2015
First published
05 Feb 2015

RSC Adv., 2015,5, 20623-20633

Author version available

Molecular insight and resolution for tumors harboring the H-ras(G12V) mutation

H. Tang and Y. Chen, RSC Adv., 2015, 5, 20623 DOI: 10.1039/C4RA16763E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements