Issue 11, 2015
From the journal:

RSC Advances

Copper-catalyzed oxidative cyclization of arylamides and β-diketones: new synthesis of 2,4,5-trisubstituted oxazoles†

Yang Bai,a   Wen Chen,a   Ya Chen,a   Huawen Huang,a   Fuhong Xiaoa  and  Guo-Jun Deng*a  

* Corresponding authors

a Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China
E-mail: gjdeng@xtu.edu.cn
Fax: +86-731-58292251

Abstract

A novel copper catalyzed approach to oxazoles via enamide intermediates was developed from benzamides and β-diketones. The successive condensation and cyclization reactions afforded various 2,4,5-trisubstituted oxazoles in good yields.

Graphical abstract: Copper-catalyzed oxidative cyclization of arylamides and β-diketones: new synthesis of 2,4,5-trisubstituted oxazoles

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Article information

DOI
https://doi.org/10.1039/C4RA14394A
Article type
Communication
Submitted
12 Nov 2014
Accepted
18 Dec 2014
First published
19 Dec 2014

RSC Adv., 2015,5, 8002-8005

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Copper-catalyzed oxidative cyclization of arylamides and β-diketones: new synthesis of 2,4,5-trisubstituted oxazoles

Y. Bai, W. Chen, Y. Chen, H. Huang, F. Xiao and G. Deng, RSC Adv., 2015, 5, 8002 DOI: 10.1039/C4RA14394A

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