Issue 5, 2015

Quantitative assessment of photostability and photostabilisation of Fluvoxamine and its design for actinometry

Abstract

Despite the numerous concerns that have been raised in relation to considering 0th, 1st and 2nd-order kinetic treatments for photodegradation characterisation and assessment of drugs, they still are employed, as they are the only tools available for these types of studies. The recently developed Φ-order kinetic models have opened new perspectives in the treatment of photoreaction kinetics and stand as the best known alternative to the classical approach. The Φ-order kinetics have been applied here to Fluvoxamine (Fluvo) with the aim of setting out a detailed and comprehensive procedure capable of rationalising photodegradation/photostability of drugs and proposing a platform for photosafety studies. Our results prove that quantum yields of drugs (0.0016 < Image ID:c5pp00022j-t3.gif < 0.43) should a priori be considered wavelength-dependent; their photostabilisation (up to 75% for Fluvo) by means of absorption competitors can explicitly be related to a decrease of the photokinetic factor, and photoreversible drugs can be developed into efficient actinometers (as Fluvoxamine in the 260–290 nm range). A pseudo-rate-constant factor was proposed as a descriptive parameter, circumventing the limitations of overall rate-constants and allowing a comparison between kinetic data of drugs obtained under different conditions.

Graphical abstract: Quantitative assessment of photostability and photostabilisation of Fluvoxamine and its design for actinometry

Article information

Article type
Paper
Submitted
16 Jan 2015
Accepted
08 Mar 2015
First published
09 Mar 2015

Photochem. Photobiol. Sci., 2015,14, 982-994

Author version available

Quantitative assessment of photostability and photostabilisation of Fluvoxamine and its design for actinometry

M. Maafi and W. Maafi, Photochem. Photobiol. Sci., 2015, 14, 982 DOI: 10.1039/C5PP00022J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements