Issue 20, 2015
From the journal:

Organic & Biomolecular Chemistry

Heteroatom-substituted tetra(3,4-pyrido)porphyrazines: a stride toward near-infrared-absorbing macrocycles†

Lenka Vachova,a   Miloslav Machacek,b   Radim Kučera,a   Jiri Demuth,c   Pavel Cermak,c   Kamil Kopecky,a   Miroslav Miletin,a   Adela Jedlickova,b   Tomas Simunek,b   Veronika Novakova*c  and  Petr Zimcik*a  

* Corresponding authors

a Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, Hradec Kralove, Czech Republic
E-mail: petr.zimcik@faf.cuni.cz
Fax: +420 495067167
Tel: +420 495067257

b Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, Hradec Kralove, Czech Republic

c Department of Biophysics and Physical Chemistry, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, Hradec Kralove, Czech Republic
E-mail: veronika.novakova@faf.cuni.cz
Fax: +420 495067167
Tel: +420 495067380

Abstract

A synthesis procedure for heteroatom-substituted tetra(3,4-pyrido)porphyrazines that absorb light near 800 nm was developed. Based on the observed relationships between the structure and photophysical parameters, a novel highly photodynamically active (IC50 = 0.26 μM) compound was synthesized and biologically characterized.

Graphical abstract: Heteroatom-substituted tetra(3,4-pyrido)porphyrazines: a stride toward near-infrared-absorbing macrocycles

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Article information

DOI
https://doi.org/10.1039/C5OB00651A
Article type
Communication
Submitted
01 Apr 2015
Accepted
08 Apr 2015
First published
09 Apr 2015

Org. Biomol. Chem., 2015,13, 5608-5612

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Heteroatom-substituted tetra(3,4-pyrido)porphyrazines: a stride toward near-infrared-absorbing macrocycles

L. Vachova, M. Machacek, R. Kučera, J. Demuth, P. Cermak, K. Kopecky, M. Miletin, A. Jedlickova, T. Simunek, V. Novakova and P. Zimcik, Org. Biomol. Chem., 2015, 13, 5608 DOI: 10.1039/C5OB00651A

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