We describe a ds-oligonucleotide–peptide conjugate that is able to efficiently dismount preformed DNA complexes of the bZIP regions of oncoproteins c-Fos and c-Jun (AP-1), and therefore might be useful as disrupters of AP-1-mediated gene expression pathways.
E. Pazos, C. Portela, C. Penas, M. E. Vázquez and J. L. Mascareñas, Org. Biomol. Chem., 2015, 13, 5385 DOI: 10.1039/C5OB00318K
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