A simple and efficient process for an exclusive mono-Michael addition of active methylene compounds to conjugated esters, nitriles and ketones is developed. An ionic liquid-mediated reaction is carried out at room temperature. A reaction carried out at 60 °C resulted in a double-addition product. A mechanism is proposed and supported by P31 and DOSY NMR analysis of the used ionic liquid.
A. D. Sawant, S. D. Jagadale, U. V. Desai and M. M. Salunkhe, New J. Chem., 2015, 39, 6726 DOI: 10.1039/C5NJ01225B
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