Titanocene dichloride and poly(o-aminophenol) as a new heterogeneous cooperative catalysis system for three-component Mannich reaction

Abstract

A new heterogeneous cooperative catalysis system featuring the synergistic effect of an organometallic Lewis acid and a Brønsted acid supporter was developed. The catalysis system successfully catalyzed the direct Mannich reaction of both aromatic and aliphatic ketones in excellent yields. The catalyst can be recycled at least five times and the yield of the Mannich product remains over 90%.