Issue 83, 2015
From the journal:

Chemical Communications

Synthesis of functionalized tryptamines by Brønsted acid catalysed cascade reactions†

Nicola Melis,a   Francesco Secci,a   Thomas Boddaert,b   David J. Aitkenb  and  Angelo Frongia*a  

* Corresponding authors

a Dipartimento di Scienze Chimiche e Geologiche, Università degli studi di Cagliari, Complesso Universitario di Monserrato, S.S. 554, Bivio per Sestu, I-09042, Monserrato, Cagliari, Italy
E-mail: afrongia@unica.it

b CP3A Organic Synthesis Group, ICMMO – CNRS UMR 8182, Université Paris Sud, 15 rue Georges Clemenceau, 91405 Orsay cedex, France

Abstract

An original synthetic protocol has been developed for the preparation of highly functionalized tryptamines from 2-hydroxycyclobutanone and secondary arylamines via a solvent-free Brønsted acid catalysed two-step reaction sequence.

Graphical abstract: Synthesis of functionalized tryptamines by Brønsted acid catalysed cascade reactions

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Article information

DOI
https://doi.org/10.1039/C5CC06855J
Article type
Communication
Submitted
14 Aug 2015
Accepted
26 Aug 2015
First published
26 Aug 2015

Chem. Commun., 2015,51, 15272-15275

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Synthesis of functionalized tryptamines by Brønsted acid catalysed cascade reactions

N. Melis, F. Secci, T. Boddaert, D. J. Aitken and A. Frongia, Chem. Commun., 2015, 51, 15272 DOI: 10.1039/C5CC06855J

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