Issue 54, 2015

Cationic star copolymers based on β-cyclodextrins for efficient gene delivery to mouse embryonic stem cell colonies

Abstract

A cationic star copolymer with a β-cyclodextrin core was developed for nonviral gene transfer to mouse embryonic stem cells (mESCs). The copolymer comprises poly(2-dimethyl aminoethyl methacrylate) as the cationic component and poly(2-hydroxyethyl methacrylate) as the non-toxic stealth component. These materials have very low toxicity and show highly efficient transfection to mESC colonies.

Graphical abstract: Cationic star copolymers based on β-cyclodextrins for efficient gene delivery to mouse embryonic stem cell colonies

Supplementary files

Article information

Article type
Communication
Submitted
06 May 2015
Accepted
21 May 2015
First published
21 May 2015

Chem. Commun., 2015,51, 10815-10818

Cationic star copolymers based on β-cyclodextrins for efficient gene delivery to mouse embryonic stem cell colonies

X. J. Loh and Y. Wu, Chem. Commun., 2015, 51, 10815 DOI: 10.1039/C5CC03686K

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