Issue 40, 2015
From the journal:

Chemical Communications

Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens†

M. Kavruk,ab   O. Celikbicak,c   V. C. Ozalp,*d   B. A. Borsa,d   F. J. Hernandez,e   G. Bayramoglu,f   B. Salihc  and  M. Y. Aricag  

* Corresponding authors

a Department of Biotechnology, Middle East Technical University, Turkey

b Test and Calibration Center, Turkish Standards Institution (TSE), Gebze, Kocaeli, Turkey

c Department of Chemistry, Hacettepe University, 06800 Ankara, Turkey

d School of Medicine, Istanbul Kemerburgaz University, Istanbul, Turkey
E-mail: cengizozalp@gmail.com
Fax: +90 212 4458171
Tel: +90 212 6040100/1404

e Biodonostia Research Institute, Dr. Beguiristain s/n, Donostia San Sebastian, Spain

f Department of Chemistry, Faculty of Sciences, Gazi University, 06500 Teknikokullar, Ankara, Turkey

g Biochemical Processing and Biomaterial Research Laboratory, Gazi University, 06500 Teknikokullar, Ankara, Turkey

Abstract

In this study, we designed aptamer-gated nanocapsules for the specific targeting of cargo to bacteria with controlled release of antibiotics based on aptamer–receptor interactions. Aptamer-gates caused a specific decrease in minimum inhibitory concentration (MIC) values of vancomycin for Staphylococcus aureus when mesoporous silica nanoparticles (MSNs) were used for bacteria-targeted delivery.

Graphical abstract: Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens

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Article information

DOI
https://doi.org/10.1039/C5CC01869B
Article type
Communication
Submitted
04 Mar 2015
Accepted
09 Apr 2015
First published
09 Apr 2015

Chem. Commun., 2015,51, 8492-8495

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Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens

M. Kavruk, O. Celikbicak, V. C. Ozalp, B. A. Borsa, F. J. Hernandez, G. Bayramoglu, B. Salih and M. Y. Arica, Chem. Commun., 2015, 51, 8492 DOI: 10.1039/C5CC01869B

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