We report on an iconoclastic strategy for inhibiting proteases via autolysis acceleration. We show that proteases can be concentrated and induced to rapidly self-digest by a biocompatible polymer serving as an efficient catalyst. This new generation of protease inhibitors may find applications in the treatment of various protease-dependent diseases.
Y. Lv, J. Zhang, H. Wu, S. Zhao, Y. Song, S. Wang, B. Wang, G. Lv and X. Ma, Chem. Commun., 2015, 51, 5959 DOI: 10.1039/C5CC01448D
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