Issue 61, 2015
From the journal:

Chemical Communications

Selective photosensitization through an AND logic response: optimization of the pH and glutathione response of activatable photosensitizers†

Sundus Erbas-Cakmak,a   Fatma Pir Cakmak,b   Seda Demirel Topel,c   Taha Bilal Uyara  and  Engin U. Akkaya*ab  

* Corresponding authors

a UNAM-National Nanotechnology Research Center, Bilkent University, Ankara, Turkey
E-mail: eua@fen.bilkent.edu.tr

b Department of Chemistry, Bilkent University, Ankara, Turkey

c Akdeniz University, Department of Chemistry, Antalya, Turkey

Abstract

A series of pH and GSH responsive photosensitizers were designed and synthesized. pKa values were optimized by adjusting the inductive contribution of substituents to reach a pH range (6.0–7.4) relevant to the tumour microenvironment. pH-Activatable behaviour and redox mediated release of the quencher from the PS by GSH allow the construction of an AND logic operator for selective photodynamic action in aqueous solutions.

Graphical abstract: Selective photosensitization through an AND logic response: optimization of the pH and glutathione response of activatable photosensitizers

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5CC01261A
Article type
Communication
Submitted
10 Feb 2015
Accepted
22 Jun 2015
First published
22 Jun 2015

Chem. Commun., 2015,51, 12258-12261

Author version available

Download author version (PDF)

Permissions

Request permissions

Selective photosensitization through an AND logic response: optimization of the pH and glutathione response of activatable photosensitizers

S. Erbas-Cakmak, F. P. Cakmak, S. D. Topel, T. B. Uyar and E. U. Akkaya, Chem. Commun., 2015, 51, 12258 DOI: 10.1039/C5CC01261A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements