A facile regio- and diastereoselective four-component protocol has been developed involving an α,β-unsaturated carbonyl compound, a cyclic ether, a sulfonic acid and a halogen reagent to access highly anti-α-bromo-β-sulfoalkoxyl carbonyl derivatives. Some of these products have high toxicity against human chronic myeloid leukemia cells.
M. Sohail, Y. Zhang, G. Sun, X. Guo, W. Liu, C. Liu and Z. K. Zhao, Chem. Commun., 2015, 51, 4774 DOI: 10.1039/C4CC10403J
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