Issue 12, 2015
From the journal:

Chemical Communications

Glucose transport machinery reconstituted in cell models†

Jesper S. Hansen,‡a   Karin Elbing,‡a   James R. Thompson,b   Noah Malmstadtb  and  Karin Lindkvist-Petersson*a  

* Corresponding authors

a Department of Experimental Medical Science, Faculty of Medicine, Lund University, Box 117, Lund, Sweden
E-mail: karin.lindkvist@med.lu.se

b Mork Family Department of Chemical Engineering, and Materials Science, University of Southern California, 925 Bloom Walk, Los Angeles, CA 90089, USA

Abstract

Here we demonstrate the production of a functioning cell model by formation of giant vesicles reconstituted with the GLUT1 glucose transporter and a glucose oxidase and hydrogen peroxidase linked fluorescent reporter internally. Hence, a simplified artificial cell is formed that is able to take up glucose and process it.

Graphical abstract: Glucose transport machinery reconstituted in cell models

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Article information

DOI
https://doi.org/10.1039/C4CC08838G
Article type
Communication
Submitted
05 Nov 2014
Accepted
23 Dec 2014
First published
23 Dec 2014

Chem. Commun., 2015,51, 2316-2319

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Glucose transport machinery reconstituted in cell models

J. S. Hansen, K. Elbing, J. R. Thompson, N. Malmstadt and K. Lindkvist-Petersson, Chem. Commun., 2015, 51, 2316 DOI: 10.1039/C4CC08838G

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