Issue 102, 2014

Polyester derived from recycled poly(ethylene terephthalate) waste for regenerative medicine

Abstract

Despite advances in regenerative medicine, the cost of such therapies is beyond the reach of many patients globally in part due to the use of expensive biomedical polymers. Large volumes of poly(ethylene terephthalate) (PET) in municipal waste is a potential source of low cost polymers. A novel polyester was prepared by a catalyst-free, melt polycondensation reaction of bis(hydroxyethylene) terephthalate derived from PET post-consumer waste with other multi-functional monomers from renewable sources such as citric acid, sebacic acid and D-mannitol. The mechanical properties and degradation rate of the polyester can be tuned by varying the composition and the post-polymerization time. The polyester was found to be elastomeric, showed excellent cytocompatibility in vitro and elicited minimal immune response in vivo. Three-dimensional porous scaffolds facilitated osteogenic differentiation and mineralization. This class of polyester derived from low cost, recycled waste and renewable sources is a promising candidate for use in regenerative medicine.

Graphical abstract: Polyester derived from recycled poly(ethylene terephthalate) waste for regenerative medicine

Supplementary files

Article information

Article type
Paper
Submitted
01 Sep 2014
Accepted
21 Oct 2014
First published
21 Oct 2014

RSC Adv., 2014,4, 58805-58815

Author version available

Polyester derived from recycled poly(ethylene terephthalate) waste for regenerative medicine

K. Sarkar, S. R. Krishna Meka, A. Bagchi, N. S. Krishna, S. G. Ramachandra, G. Madras and K. Chatterjee, RSC Adv., 2014, 4, 58805 DOI: 10.1039/C4RA09560J

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