An ESR and DFT study of hydration of the 2′-deoxyuridine-5-yl radical: a possible hydroxyl radical intermediate

Lidia Chomicz; Alex Petrovici; Ian Archbold; Amitava Adhikary; Anil Kumar; Michael D. Sevilla; Janusz Rak

doi:10.1039/C4CC07089E

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An ESR and DFT study of hydration of the 2′-deoxyuridine-5-yl radical: a possible hydroxyl radical intermediate†

Lidia Chomicz,^a Alex Petrovici,^b Ian Archbold,^b Amitava Adhikary,^b Anil Kumar,^b Michael D. Sevilla*^b and Janusz Rak*^a

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* Corresponding authors

^a Department of Chemistry, University of Gdansk, 80-308 Gdansk, Poland
E-mail: janusz.rak@ug.edu.pl

^b Department of Chemistry, Oakland University, Rochester, Michigan 48309, USA
E-mail: sevilla@oakland.edu

Abstract

The mechanism of radiation-induced frank strand break formation in irradiated 5-bromo-2′-deoxyuridine (BrdU)-labelled DNA is still unclear despite the proven radiosensitizing properties of BrdU. Combination of ESR spectroscopy and quantum chemical modelling points to a simple reaction between the uridine-5-yl radical and water molecules that produces the genotoxic hydroxyl radical.

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Article information

DOI: https://doi.org/10.1039/C4CC07089E
Article type: Communication
Submitted: 08 Sep 2014
Accepted: 01 Oct 2014
First published: 01 Oct 2014

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Chem. Commun., 2014,50, 14605-14608

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An ESR and DFT study of hydration of the 2′-deoxyuridine-5-yl radical: a possible hydroxyl radical intermediate

L. Chomicz, A. Petrovici, I. Archbold, A. Adhikary, A. Kumar, M. D. Sevilla and J. Rak, Chem. Commun., 2014, 50, 14605 DOI: 10.1039/C4CC07089E

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Chemical Communications

An ESR and DFT study of hydration of the 2′-deoxyuridine-5-yl radical: a possible hydroxyl radical intermediate†

Abstract

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An ESR and DFT study of hydration of the 2′-deoxyuridine-5-yl radical: a possible hydroxyl radical intermediate

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