Issue 93, 2014
From the journal:

Chemical Communications

Multiplex SNP detection in multiple codons for accurate drug therapy†

Danishmalik Rafiq Sayyed,a   Satish Balasaheb Nimse,a   Keum-Soo Song,b   Nackmoon Sungc  and  Taisun Kim*a  

* Corresponding authors

a Institute for Applied Chemistry and Department of Chemistry, Hallym University, Chuncheon, Korea
E-mail: tskim@hallym.ac.kr
Fax: +82-33-256-3421

b Biometrix Technology, Inc., 202 BioVenture Plaza, Chuncheon, Korea

c National Masan Hospital, Clinical Research Center, Changwon, Korea

Abstract

Multiplex SNP discrimination in the multiple codons of the genomic DNA is demonstrated by applying controller DNA technology (CDT) to MDR-TB 9G DNAChips. CDT allowed the efficient detection of 20 SNPs in five codons of the genomic DNA in 40 min. CDT could distinguish SNP targets to as low as 1 copy of the genomic DNA. 100% agreement with the sequencing analysis of clinical samples highlighted the clinical applicability of MDR-TB 9G DNAChips.

Graphical abstract: Multiplex SNP detection in multiple codons for accurate drug therapy

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Article information

DOI
https://doi.org/10.1039/C4CC06625A
Article type
Communication
Submitted
22 Aug 2014
Accepted
24 Sep 2014
First published
24 Sep 2014

Chem. Commun., 2014,50, 14585-14588

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Multiplex SNP detection in multiple codons for accurate drug therapy

D. R. Sayyed, S. B. Nimse, K. Song, N. Sung and T. Kim, Chem. Commun., 2014, 50, 14585 DOI: 10.1039/C4CC06625A

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