An umpolung approach toward nitrone construction utilizing a phosphine-mediated addition of 1,2-dicarbonyls to nitroso compounds is reported. The reaction exhibits a high degree of chemoselectivity and provides direct access to isoxazolidines, imines, and trisubstituted alkenes.
A. P. Chavannavar, A. G. Oliver and B. L. Ashfeld, Chem. Commun., 2014, 50, 10853 DOI: 10.1039/C4CC05044D
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