Issue 35, 2014

Anti-cancer therapeutic potential of quinazoline based small molecules via global upregulation of miRNAs

Abstract

Three quinazoline based small molecules showed global upregulation of miRNA expression with a selective enrichment of tumor suppressor miRNAs. The target genes of the upregulated miRNAs were predicted to be enriched for apoptotic pathways. Apoptotic induction following treatment with quinazoline compounds was confirmed by in cellulo studies. Thus, these small molecules having the core structural moiety (2,4-diphenyl-quinazoline) can be used as scaffolds to design activators of miRNA expression paving the way for novel anti-cancer drugs.

Graphical abstract: Anti-cancer therapeutic potential of quinazoline based small molecules via global upregulation of miRNAs

Supplementary files

Article information

Article type
Communication
Submitted
09 Dec 2013
Accepted
28 Feb 2014
First published
11 Mar 2014

Chem. Commun., 2014,50, 4639-4642

Anti-cancer therapeutic potential of quinazoline based small molecules via global upregulation of miRNAs

S. Nahar, D. Bose, S. Kumar Panja, S. Saha and S. Maiti, Chem. Commun., 2014, 50, 4639 DOI: 10.1039/C3CC49337G

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