A multifunctional perylenediimide derivative (DTPDI) can be used as a recyclable specific Hg2+ ion sensor and an efficient DNA delivery carrier

Abstract

Multifunctional dithioacetal-modified perylenediimide (DTPDI) is synthesized as a highly sensitive and selective fluorescent chemosensor for recyclable Hg²⁺ detection and an effective DNA carrier. The central PDI chromophore allows the tracing of cell uptake by fluorescence microscopy, dithioacetals enable the detection of Hg²⁺, and peripheral amine hydrochloride salts increase the water solubility and also serve as positive charges for noncovalent binding of negatively charged DNA. In addition to serve as a recyclable fluorescent probe for Hg²⁺ detection, DTPDI can be rapidly internalized into live cells with low cytotoxicity and high DNA delivery efficacy.