The last 2–3 years have seen numerous relationships develop between organometallic chemists, fluorine chemists and PET Centers around the world. These collaborations have led to the development of many new strategies for the late-stage introduction of fluorine-18 into complex bioactive molecules. In this perspective we highlight recent developments and key milestones since 2011.
![Graphical abstract: Late-stage [18F]fluorination: new solutions to old problems](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C4SC02099E&imageInfo.ImageIdentifier.Year=2014)
A. F. Brooks, J. J. Topczewski, N. Ichiishi, M. S. Sanford and P. J. H. Scott, Chem. Sci., 2014, 5, 4545 DOI: 10.1039/C4SC02099E
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