Issue 104, 2014

Acid promoted cyclodehydration of amino alcohols with amide acetal

Abstract

A convenient acid-promoted cyclization protocol for the formation of azaheterocycles from amino alcohols is described. The reaction involves the use of N,N-dimethylacetamide dimethyl acetal (DMADA) as the activating reagent of the hydroxyl group. Using this protocol, pyrrolidines or piperidines with various substituents can be synthesized in good to high yields.

Graphical abstract: Acid promoted cyclodehydration of amino alcohols with amide acetal

Supplementary files

Article information

Article type
Paper
Submitted
17 Sep 2014
Accepted
06 Nov 2014
First published
06 Nov 2014

RSC Adv., 2014,4, 60017-60024

Author version available

Acid promoted cyclodehydration of amino alcohols with amide acetal

S. Hwang, H. Park, Y. Kwon and S. Kim, RSC Adv., 2014, 4, 60017 DOI: 10.1039/C4RA10625C

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