Issue 52, 2014

A general, simple and green process to access pyrrolo[2,1-a]isoquinolines using a KI/TBHP catalytic system

Abstract

A novel KI/TBHP-catalyzed 1,3-dipolar cycloaddition/oxidation/aromatization cascade reaction provided general, efficient and green access to biologically important pyrrolo[2,1-a]isoquinolines. The product pyrrolo[2,1-a]isoquinolines were obtained from reactions between simple, readily available dipolarophiles and tetrahydroisoquinolines in moderate to excellent yields The reaction was environmentally benign in the adoption of nontoxic KI as a catalyst and IOH was generated in situ from the oxidation reaction of KI and TBHP.

Graphical abstract: A general, simple and green process to access pyrrolo[2,1-a]isoquinolines using a KI/TBHP catalytic system

Supplementary files

Article information

Article type
Paper
Submitted
16 Apr 2014
Accepted
10 Jun 2014
First published
11 Jun 2014

RSC Adv., 2014,4, 27250-27258

Author version available

A general, simple and green process to access pyrrolo[2,1-a]isoquinolines using a KI/TBHP catalytic system

H. Huang, F. Huang, Y. Li, J. Jia, Q. Ye, L. Han and J. Gao, RSC Adv., 2014, 4, 27250 DOI: 10.1039/C4RA03455D

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